منابع مشابه
Hematopoiesis and Stem Cells
Fancc suppresses cross-linker–induced genotoxicity, modulates growth-inhibitory cytokine responses, and modulates endotoxin responses. Although loss of the latter function is known to account for endotoxininduced marrow failure in murine Fancc (mFancc)–deficient mice, some argue that cytokine and endotoxin hypersensitivities devolve simply from genomic instability. Seeking to resolve this quest...
متن کاملHematopoiesis and Stem Cells
1Genome Instability and DNA Repair Group, Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain; 2Centre for Biomedical Network Research on Rare Diseases, Instituto de Salud Carlos III, Bellaterra, Barcelona, Spain; 3Institut de Génétique Médicale, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire de Lille, Lille, France; 4Gé...
متن کاملHematopoiesis and Stem Cells
CD41 expression is associated with the earliest stages of mouse hematopoiesis. It is notably expressed on some cells of the intra-aortic hematopoietic clusters, an area where the first adult-repopulating hematopoietic stem cells (HSCs) are generated. Although it is generally accepted that CD41 expression marks the onset of primitive/definitive hematopoiesis, there are few published data concern...
متن کاملHematopoiesis and Stem Cells
Runx1 is required for the emergence of hematopoietic stem cells (HSCs) from hemogenic endothelium during embryogenesis. However, its role in the generation and maintenance of HSCs during adult hematopoiesis remains uncertain. Here, we present analysis of a zebrafish mutant line carrying a truncation mutation, W84X, in runx1. The runx1W84X/W84X embryos showed blockage in the initiation of defini...
متن کاملHematopoiesis and Stem Cells
The low incidence of CFU-F significantly complicates the isolation of homogeneous populations of mouse bone marrow stromal cells (BMSCs), a common problem being contamination with hematopoietic cells. Taking advantage of burgeoning evidence demonstrating the perivascular location of stromal cell stem/ progenitors, we hypothesized that a potential reason for the low yield of mouse BMSCs is the f...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2019
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2018.08.005